Synthesis of spiro[2,3-dihydrofuran-3,3′-oxindole] derivatives via a multi-component cascade reaction of α-diazo esters, water, isatins and malononitrile/ethyl cyanoacetate
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DOI: 10.1039/c9gc01751h
Abstract: We report a green synthesis of spiro[2,3-dihydrofuran-3,3′-oxindole] derivatives which are of potential value in medicinal chemistry. read more here.
Keywords: oxindole derivatives; spiro dihydrofuran; synthesis spiro; dihydrofuran oxindole ... See more keywords
A facile approach to spiro[dihydrofuran-2,3'-oxindoles] via formal [4 + 1] annulation reaction of fused 1H-pyrrole-2,3-diones with diazooxindoles
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DOI: 10.3762/bjoc.18.162
Abstract: There has been developed an easy synthetic approach to spiro[dihydrofuran-2,3'-oxindoles] via a highly diastereoselective formal [4 + 1] cycloaddition reaction of [e]-fused 1H-pyrrole-2,3-diones with diazooxindoles. The described novel heterocyclic systems are heteroanalogues of antimicrobial and… read more here.
Keywords: pyrrole diones; oxindoles via; reaction; spiro dihydrofuran ... See more keywords