Ag(I)/PPh3-catalyzed diastereoselective syntheses of spiro[indole-3,4'-piperidine] derivatives via cycloisomerizations of tryptamine-ynamides.
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DOI: 10.1039/d1cc07298f
Abstract: A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4'-piperidine] scaffold in a racemic and diastereoselective manner. The diastereoselective products were achieved by a chiron approach. Density functional theory (DFT) calculations indicated that… read more here.
Keywords: diastereoselective syntheses; catalyzed diastereoselective; indole piperidine; pph3 catalyzed ... See more keywords
Ru(II)-catalyzed regioselective [4 + 1] redox-neutral spirocyclization of aryl amidines with diazopyrazolones: direct access to spiro[indole-3,4'-pyrazol]-5'-ones
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DOI: 10.1039/d3qo02071a
Abstract: An efficient protocol to construct spiro[indole-3,4'-pyrazol]-5'-ones via ruthenium(II)-catalyzed selective C-H bond activation/[4 + 1] spirocyclization starting from easily available N-aryl amidines and diazopyrazolones has been developed. A series of spiro-pyrazolones... read more here.
Keywords: indole pyrazol; amidines diazopyrazolones; spiro indole; aryl amidines ... See more keywords
New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28073161
Abstract: The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds. The four-component reaction of 5-R-isatins (R = H, CH3), malononitrile,… read more here.
Keywords: spiro indole; cyano; pyridine; pyridine carboxamides ... See more keywords