An Efficient Synthesis of 6′‐methyl‐1'H‐spiro[indoline‐3,4′‐pyrimidine]‐2,2′(3'H)‐dione Derivatives
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DOI: 10.1002/jhet.2944
Abstract: The reactions of isatins, urea and 1-(piperidin-1-yl)butane-1,3-dione or 1-morpholinobutane-1,3-dione have been developed for the preparation of spiroheterocycles compounds. It was found these reactions could be given higher yields and required shorter time in our process.… read more here.
Keywords: dione; efficient synthesis; methyl spiro; spiro indoline ... See more keywords
Ratiometric Cu2+ Binding, Cell Imaging, Mitochondrial Targeting, and Anticancer Activity with Nanomolar IC50 by Spiro-Indoline-Conjugated Calix[4]arene
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DOI: 10.1021/acsomega.9b01402
Abstract: A triazole-derivatized, spiro-indoline-linked, 1,3-di-derivative of calix[4]arene (L) has been synthesized to take advantage of its ion-binding capability in the ring-open form. Indeed, the spiro-indoline moiety is well known for its photochromic, acidochromic, and metallochromic properties.… read more here.
Keywords: cu2; cell; calix arene; spiro indoline ... See more keywords
Synthesis of spiro(indoline-2,3′-hydropyridazine) via an “on-water” [4 + 2] annulation reaction
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DOI: 10.1039/d0qo01422b
Abstract: An on-water [4 + 2] annulation reaction between 2-methyl-3H-indolium salt and α-bromo N-acyl hydrazone has been developed. The environmentally friendly strategy provides the first facile access to spiro(indoline-2,3'-hydropyridazine) scaffolds. read more here.
Keywords: indoline hydropyridazine; annulation reaction; water annulation; spiro indoline ... See more keywords
Photochromic spiro-indoline naphthoxazines and naphthopyrans in dye-sensitized solar cells
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DOI: 10.1039/d2qm00375a
Abstract: Photochromic dyes possess unique properties that can be exploited in different domains, including optics, biomedicine and optoelectronics. Herein, we explore the potential of photochromic spiro-indoline naphthoxazine (SINO) and naphthopyran (NIPS) for application in photovoltaics. We… read more here.
Keywords: spiro indoline; photochromic spiro; indoline naphthoxazines; naphthopyrans dye ... See more keywords
Catalyst-free glycerol-mediated green synthesis of 5′-thioxospiro[indoline-3,3′-[1,2,4]triazolidin]-2-ones/spiro[indoline-3,3′-[1,2,4]triazolidine]-2,5′-diones
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic Communications"
DOI: 10.1080/00397911.2017.1359844
Abstract: ABSTRACT The development of new catalyst-free green and efficient protocol to access 5′-thioxospiro[indoline-3,3′-[1,2,4]triazolidin]-2-ones/spiro[indoline-3,3′-[1,2,4]triazolidine]-2,5′-diones, potential privileged scaffolds for drug discovery, is disclosed. Key feature of this methodology is the dual use of glycerol—a recyclable, bioorganic compound,… read more here.
Keywords: ones spiro; indoline triazolidin; spiro indoline; thioxospiro indoline ... See more keywords
Cu(II)-β-cyclodextrin-catalyzed synthesis of spiro[indoline-3,4′-pyrano[3,2-c]chromene]-3′-carbonitrile derivatives
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DOI: 10.1080/00397911.2017.1373822
Abstract: ABSTRACT Cu(II)-β-cyclodextrin-catalyzed synthesis of spiro[indoline-3,4′-pyrano[3,2-c]chromene]-3′-carbonitriles through the reaction of isatin derivatives, 4-hydroxycoumarin, and malononitrile in ethanol at room temperature. GRAPHICAL ABSTRACT read more here.
Keywords: indoline pyrano; spiro indoline; synthesis spiro; catalyzed synthesis ... See more keywords
A one-pot three-component synthesis of fused Spiro-Indoline/Indene derivatives derived from ethynyl azaindole by 1,3-dipolar cycloaddition reaction
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1508722
Abstract: Abstract A one-pot method for the simple, efficient, and environmentally benign protocol for the synthesis of Spiro-Indoline/Indene derivatives containing Aza indole moiety as a side chain is outlined. The 1,3-dipolar cycloaddition reaction of azomethine ylides… read more here.
Keywords: indoline indene; spiro indoline; reaction; one pot ... See more keywords