Synthesis and Evaluation of Novel Spiro[oxindole-isoxazolidine] Derivatives as Potent Antioxidants
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DOI: 10.1002/jhet.2712
Abstract: The antioxidant activity of isatin derivatives can be described with the presence of enolic hydroxyl group at the second position of the ring because of the keto-enol tautomerism between NH and CO groups of indolone… read more here.
Keywords: novel spiro; isoxazolidine derivatives; oxindole isoxazolidine; synthesis evaluation ... See more keywords
Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors
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DOI: 10.1002/open.201900344
Abstract: Abstract Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats. The majority… read more here.
Keywords: oxindole dihydroquinazolinones; irap inhibitors; evaluation proposed; irap ... See more keywords
Ring-opening cyclization of activated spiro-aziridine oxindoles with heteroarenes: a facile synthetic approach to spiro-oxindole-fused pyrroloindolines
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DOI: 10.1039/d0ra00684j
Abstract: Herein, we report a facile tandem approach for the synthesis of both spiro-oxindole-fused pyrroloindolines and benzofurano-pyrrolidines via a Lewis acid-catalyzed domino ring-opening with concomitant ring annulation using activated spiro-aziridines and heteroarenes. This method offers a… read more here.
Keywords: ring opening; activated spiro; oxindole fused; approach ... See more keywords
Synthesis of Cholestan -3-One Derivatives Possessing a C-2 Spiro-Oxindole Substituent
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DOI: 10.3184/174751918x15161933697781
Abstract: A series of C-2 cholestan-3-one spiro-oxindole derivatives were prepared by the 1:3 dipolar cycloaddition reaction between the cholestan-3-one substituted by a C-2 arylidene and the azomethine ylid derived from isatin and sarcosine. The dipolarophiles were… read more here.
Keywords: cholestan one; one derivatives; possessing spiro; derivatives possessing ... See more keywords