Highly diastereoselective synthesis of trifluoromethyl containing spiro[pyrrolidin-3,2′-oxindoles] from N-2,2,2-trifluoroethylsubstituted isatin imines and β,γ-unsaturated α-keto esters
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DOI: 10.1016/j.tet.2021.132112
Abstract: ABSTRACT Inspired by the chemistry and biology of fluorine-containing molecules and pyrrolidinyl spirooxindoles, herein we report a highly diastereoselective [3+2] cycloaddition reaction of β,γ-unsaturated α-keto esters and N-2,2,2-trifluoroethylisatin ketimines in the presence of the catalyst… read more here.
Keywords: spiro pyrrolidin; highly diastereoselective; keto esters; pyrrolidin oxindoles ... See more keywords