Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors.
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DOI: 10.1016/j.ejmech.2016.11.010
Abstract: A novel series of dihydro-1,3,5-triazine derivatives bearing a heteroatom spiro-ring were designed and synthesized on the basis of molecular flexible docking work, and their biological activities were evaluated. Compounds A2, A5, B1 and B3 showed… read more here.
Keywords: novel; design synthesis; dihydro; synthesis docking ... See more keywords