Ag-Catalyzed Oxidative ipso-Cyclization via Decarboxylative Acylation/Alkylation: Access to 3-Acyl/Alkyl-spiro[4.5]trienones.
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DOI: 10.1021/acs.orglett.0c01588
Abstract: A strategy to functionalized spiro[4.5]trienones, by domino silver-catalyzed decarboxylative acylation or alkylation/ ipso-cyclization of N-arylpropiolamides with α-keto acids/alkyl carboxylic acids, is presented. This transformation offers a wide range of substituted 3-acyl/alkyl-spiro[4.5]trienones in high yields with… read more here.
Keywords: acylation alkylation; ipso cyclization; decarboxylative acylation; alkyl spiro ... See more keywords
Synthesis of Difluoromethylated and Phosphorated Spiro[5.5]trienones via Dearomative Spirocyclization of Biaryl Ynones.
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DOI: 10.1021/acs.orglett.8b01027
Abstract: Copper- or silver-catalyzed cascade radical addition/dearomative spirocyclization of biaryl ynones with fluoroalkyl bromides or diethylphosphite has been realized for the first time. This method provides a novel and step-economical protocol for the divergent synthesis of… read more here.
Keywords: spirocyclization biaryl; biaryl ynones; phosphorated spiro; dearomative spirocyclization ... See more keywords
Visible-light promoted one-pot synthesis of sulfonated spiro[4,5]trienones from propiolamides, anilines and sulfur dioxide under transition metal-free conditions.
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DOI: 10.1039/c9cc05949k
Abstract: A novel visible-light promoted sulfonylation/ipso-cyclization of N-arylpropiolamides with arylamines and DABCO·(SO2)2 to synthesize various sulfonated spiro[4,5]trienones is reported. This sulfonylation/ipso-cyclization reaction proceeds via a radical process and undergoes arylsulfonyl radical formation, sulfonylation, and ipso-cyclization. The… read more here.
Keywords: ipso cyclization; sulfonated spiro; sulfonylation ipso; visible light ... See more keywords