Mechanism of Palladium‐Catalyzed Spiroannulation of Naphthols with Alkynes: A Density Functional Theory Study
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DOI: 10.1002/cctc.202000613
Abstract: Pd‐catalyzed spiroannulation of bromophenylnaphthalenols with acetylenes to achieve asymmetric dearomatization is a powerful way to construct chiral spiro‐compounds. DFT calculations with the M06 functional have been performed to reveal the mechanism and enantioselectivity of this… read more here.
Keywords: enantioselectivity; mechanism palladium; spiroannulation; catalyzed spiroannulation ... See more keywords
Divergent Asymmetric Synthesis of Chiral Spiroheterocycles through Pd-Catalyzed Enantio- and Diastereoselective [3 + 2] Spiroannulation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03643
Abstract: The palladium-catalyzed divergent asymmetric synthesis of chiral spiro-furanindoline derivatives is described. The zwitterionic alkoxy π-allyl Pd(II) intermediate, generated catalytically from vinyl ethylene carbonate (VEC), could undergo ligand-controlled enantio- and diastereoselective dipolar [3 + 2] spiroannulation… read more here.
Keywords: spiroannulation; enantio diastereoselective; synthesis chiral; divergent asymmetric ... See more keywords