Chemoselective N-H or C-2 Arylation of Indole-2-carboxamides: Controllable Synthesis of Indolo[1,2- a]quinoxalin-6-ones and 2,3'-Spirobi[indolin]-2'-ones.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02197
Abstract: Novel methods involving the chemoselective N-H or C-2 arylation for the synthesis of indolo[1,2- a]quinoxalin-6-ones and 2,3'-spirobi[indolin]-2'-ones starting from indole-2-carboxamides were developed. When reactions were carried out using ZnI2 as catalyst and Ag2CO3 as oxidant,… read more here.
Keywords: quinoxalin ones; indolo quinoxalin; spirobi indolin; indolin ones ... See more keywords
Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.821518
Abstract: A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured… read more here.
Keywords: spirobi indolin; synthesis spirobi; ones preliminary; efficient synthesis ... See more keywords