N-Heterocyclic Carbene-Catalyzed Enantioselective Synthesis of Spirocyclic Ketones Bearing gem-Difluoromethylenes
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DOI: 10.1039/d3qo00503h
Abstract: An enantioselective construction of spirocyclic ketones featuring stereogenetic carbon centers bearing the gem-difluoromethylene group has been accomplished through N-heterocyclic carbene (NHC)-catalyzed umpolung [3+2] annulation of enals with cyclic gem-difluoroalkyl ketones.... read more here.
Keywords: bearing gem; gem; spirocyclic ketones; carbene catalyzed ... See more keywords