Three-Component Reactions to Spirocyclic Pyrrolidinonylformimidamides: α-Isocyano Lactams as Two-Atom Unit in Silver-Catalyzed Formal [3 + 2] Cycloaddition Reactions.
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DOI: 10.1021/acs.orglett.8b03118
Abstract: A facile approach to spirocyclic pyrrolidinonylformimidamides has been developed via three-component reactions of isocyanides, alkenes, and amines. The reaction proceeds through a sequence of two distinct reaction pathways; the base-catalyzed conjugate addition of α-isocyano lactams… read more here.
Keywords: cycloaddition; spirocyclic pyrrolidinonylformimidamides; atom unit; three component ... See more keywords