Modular Synthesis of Polar Spirocyclic Scaffolds Enabled by Radical Chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00869
Abstract: Herein, we report a highly modular strategy to access spirocyclic scaffolds from abundant starting materials, i.e., cyclic ketones and α-amino or oxamic acids. The sequence proceeds through a straightforward Knoevenagel condensation, followed by a domino… read more here.
Keywords: spirocyclic scaffolds; chemistry; polar spirocyclic; scaffolds enabled ... See more keywords
Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazin spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra02759c
Abstract: A novel approach to synthesize chiral 1,2-oxazinane spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition reaction between methyleneindolinones and γ-aminooxy-α,β-unsaturated ester has been disclosed. Furthermore, a hydrazide 1,4-synthon is designed and synthesized to construct chiral… read more here.
Keywords: spirocyclic scaffolds; scaffolds organocatalytic; hexahydropyridazin spirocyclic; chiral oxazinane ... See more keywords