Synthesis of spirocyclic β- and γ-sultams by one-pot reductive cyclization of cyanoalkylsulfonyl fluorides.
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DOI: 10.1002/ejoc.202000351
Abstract: One-pot intramolecular cyclization of novel sp3-enriched cyanoalkylsulfonyl fluorides into spirocyclic β- or γ-sultams is disclosed. The method relies on nitrile group reduction followed by sulfonylation of amino group thus formed upon mild conditions (NaBH4, NiCl2·6H2O… read more here.
Keywords: spirocyclic sultams; one pot; cyclization; cyanoalkylsulfonyl fluorides ... See more keywords