Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies.
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DOI: 10.1016/j.ejmech.2018.07.069
Abstract: This paper describes the rational development of a series of novel spiroindoline derivatives endowed with selective inhibitory activity on the HDAC6 isoform. A convenient multicomponent one-pot protocol was applied for the assembly of the desired… read more here.
Keywords: inhibitors synthesis; hdac inhibitors; novel spiroindoline; spiroindoline hdac ... See more keywords