Combretastatin A-4: The Antitubulin Agent that Inspired the Design and Synthesis of Styrene and Spiroisatin Hybrids as Promising Cytotoxic, Antifungal and Antiviral Compounds
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DOI: 10.21577/0103-5053.20190265
Abstract: The design of a series of styrene and spiroisatin hybrids was based on the structure of combretastatin A-4 1. This library of 20 compounds were synthesized with the pharmacophoric units: 3,4,5-trimethoxy or/and 4-hydroxy-3-methoxy phenyl moities… read more here.
Keywords: styrene spiroisatin; spiroisatin; antifungal antiviral; spiroisatin hybrids ... See more keywords