Chiral Squaramide Catalyzed Asymmetric Spiroketalization toward Aromatic [6,5] Spiroketals.
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DOI: 10.1021/acs.orglett.2c00074
Abstract: Herein is disclosed an efficient enantio- and diastereoselective spiroketalization of aromatic ketone tethered to ortho-homoformyl and enone moiety via in situ enol formation using quinine derived squaramide organocatalyst to access aromatic [6,5] spiroketals with complete… read more here.
Keywords: spiroketalization; asymmetric spiroketalization; aromatic spiroketals; catalyzed asymmetric ... See more keywords
Ir-Catalyzed Asymmetric Cascade Allylation/Spiroketalization Reaction for Stereoselective Synthesis of Oxazoline-Spiroketals.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03885
Abstract: An asymmetric cascade allylation/spiroketalization reaction between 2-(1-hydroxyallyl)phenols and 5-methyleneoxazolines is accomplished by using a chiral Ir(I) catalyst derived from commercially available iridium precursor and the Carreira ligand. This protocol furnishes a class of structurally novel… read more here.
Keywords: allylation spiroketalization; spiroketalization; reaction; spiroketalization reaction ... See more keywords