Palladium-Catalyzed Hydrocarbonylative Spirolactonization for Expedite Construction of Oxaspirolactones.
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DOI: 10.1021/acs.orglett.3c00019
Abstract: A novel palladium-catalyzed cascade hydrocarbonylation of the alkene moiety followed by intramolecular spirolactonization of 2-vinylaryl hydroxyalkyl ketones has been developed, which offers efficient and expedited access to furnishing oxaspirolactones in high yields with high chemoselectivities.… read more here.
Keywords: hydrocarbonylative spirolactonization; spirolactonization; palladium catalyzed; expedite construction ... See more keywords