A machine learning derived echocardiographic algorithm identifies people at risk of heart failure with distinct cardiac structure, function, and response to spironolactone: findings from the HOMAGE trial.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of heart failure"
DOI: 10.1002/ejhf.2859
Abstract: BACKGROUND An echocardiographic algorithm derived by machine learning (e'VM) characterizes preclinical individuals with different cardiac structure and function, biomarkers, and long-term risk of heart failure (HF). Our aim was the external validation of the e'VM… read more here.
Keywords: heart failure; spironolactone; algorithm; trial ... See more keywords
Monitoring renal safety in mineralocorticoid receptor antagonist trials
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.764
Abstract: Overall, patients with heart failure (HF) and preserved left ventricular ejection fraction (HFpEF) assigned to spironolactone in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT)1 trial did not achieve a… read more here.
Keywords: patients enrolled; safety; heart failure; monitoring renal ... See more keywords
Comparative efficacy of empagliflozin and drugs of baseline therapy in post-infarct heart failure in normoglycemic rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01873-7
Abstract: The study aimed to investigate the effects of the sodium-glucose co-transporter 2 (SGLT2) inhibitor empagliflozin on chronic heart failure (HF) in normoglycemic rats. The effects of empagliflozin were compared with the standard medications for HF,… read more here.
Keywords: normoglycemic rats; group; heart failure; empagliflozin ... See more keywords
Spironolactone and perioperative atrial fibrillation occurrence in cardiac surgery patients: Rationale and design of the ALDOCURE trial.
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DOI: 10.1016/j.ahj.2019.04.023
Abstract: BACKGROUND After artery bypass grafting (CABG), the presence of perioperative AF (POAF) is associated with greater short- and long-term cardiovascular morbidity. Underlying POAF mechanisms are complex and include the presence of an arrhythmogenic substrate, cardiac… read more here.
Keywords: spironolactone; design aldocure; surgery; aldocure trial ... See more keywords
Influence of Age on the Efficacy and Safety of Spironolactone in Heart Failure with Preserved Ejection Fraction
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DOI: 10.1016/j.cardfail.2019.07.036
Abstract: Introduction Heart failure with preserved ejection fraction (HFpEF) disproportionately affects older adults. Age-related changes in physiology and variable pharmacokinetics may affect drug efficacy and safety among older individuals. We examined efficacy and safety of spironolactone… read more here.
Keywords: spironolactone; safety; age; ejection fraction ... See more keywords
Effect of spironolactone on the risks of mortality and hospitalization for heart failure in pre-dialysis advanced chronic kidney disease: A nationwide population-based study.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.03.080
Abstract: BACKGROUND Spironolactone has been shown to reduce cardiovascular death in patients with mild-to-moderate chronic kidney disease (CKD), but its risks and benefits in advanced CKD remain unsettled. We aimed to assess whether spironolactone reduces cardiovascular… read more here.
Keywords: pre dialysis; mortality; spironolactone; person years ... See more keywords
Retrospective analysis of adverse events with spironolactone in females reported to the United States Food and Drug Administration
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Women's Dermatology"
DOI: 10.1016/j.ijwd.2020.05.002
Abstract: Background Spironolactone is an off-label acne treatment that is commonly prescribed due to its low cost, efficacy, and tolerability. Objective This study aimed to classify the most common adverse reactions associated with spironolactone in women… read more here.
Keywords: drug administration; common adverse; food drug; spironolactone ... See more keywords
Spironolactone in Patients With Heart Failure, Preserved Ejection Fraction, and Worsening Renal Function.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2020.12.057
Abstract: BACKGROUND Treatment of heart failure with preserved ejection fraction (HFpEF) with spironolactone is associated with lower risk of heart failure hospitalization (HFH) but increased risk of worsening renal function (WRF). The prognostic implications of spironolactone-associated… read more here.
Keywords: risk; treatment; spironolactone; heart failure ... See more keywords
Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives
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DOI: 10.1016/j.steroids.2016.12.010
Abstract: HIGHLIGHTSSynthetic approaches to the versatile mutitarget drug spironolactone have been reviewed.Aims to provide a comprehensive insight to the synthetic endeavors devoted to drug and its analogues/derivatives.It will help the synthetic chemist to design and prepare… read more here.
Keywords: analogues derivatives; drug; drug spironolactone; spironolactone ... See more keywords
Spironolactone voltammetric determination on renewable amalgam film electrode
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DOI: 10.1016/j.steroids.2017.12.007
Abstract: &NA; In this study a new high sensitive method of spironolactone (SP) determination is proposed using voltammetric technique. As the working electrode amalgam film silver based electrode (Hg(Ag)FE) was applied, that resulted in obtaining low… read more here.
Keywords: determination; method; spironolactone; amalgam film ... See more keywords
Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115381
Abstract: Polycystic ovarian syndrome (PCOS), is a multifactorial endocrine disorder in women of reproductive age. It usually associates with metabolic disorders (MDs), which aggravates the risk of infertility, cardiometabolic events and associated comorbidities in women with… read more here.
Keywords: low dose; endocrine metabolic; induced pcos; metabolic disturbances ... See more keywords