P1235THE IMPACT OF SPIRONOLACTONE ON DIASTOLIC FUNCTION IN HEMODIALYSIS PATIENTS - THE MIRENDA RCT
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa144.p1235
Abstract: Patients on maintenance hemodialysis (HD) treatment are particularly prone to develop cardiovascular disease. Heart failure with preserved ejection fraction (HFpEF) characterized by diastolic dysfunction (DD) is highly prevalent and lacks an effective treatment to date.… read more here.
Keywords: diastolic function; function; spironolactone treatment; patients mirenda ... See more keywords
Predicting albuminuria response to spironolactone treatment with urinary proteomics in patients with type 2 diabetes and hypertension
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DOI: 10.1093/ndt/gfw406
Abstract: Background The mineralocorticoid receptor antagonist spironolactone significantly reduces albuminuria in patients with diabetes. Prior studies have shown large between-patient variability in albuminuria treatment response. We previously developed and validated a urinary proteomic classifier that predicts… read more here.
Keywords: response spironolactone; treatment; type diabetes; spironolactone treatment ... See more keywords
COMPARISON OF SHORT-TERM EFFICACY BETWEEN ORAL SPIRONOLACTONE TREATMENT AND PHOTODYNAMIC THERAPY FOR THE TREATMENT OF NONRESOLVING CENTRAL SEROUS CHORIORETINOPATHY
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DOI: 10.1097/iae.0000000000001913
Abstract: Purpose: To compare the short-term therapeutic efficacy of oral spironolactone treatment with that of half-dose photodynamic therapy (PDT) in patients with nonresolving central serous chorioretinopathy. Methods: This retrospective, interventional, comparative study included 41 patients with… read more here.
Keywords: oral spironolactone; spironolactone; treatment; spironolactone treatment ... See more keywords
Potential spironolactone effects on collagen metabolism biomarkers in patients with uncontrolled blood pressure
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DOI: 10.1136/heartjnl-2018-313182
Abstract: Background An increase in myocardial collagen content may contribute to the development of heart failure; this might be inhibited or reversed by mineralocorticoid receptor antagonists (MRAs). We investigated changes in serum concentrations of the collagen… read more here.
Keywords: treatment; blood pressure; picp; spironolactone treatment ... See more keywords
Mineralocorticoid Receptor Antagonist Treatment for Steroid-Induced Central Serous Chorioretinopathy Patients with Continuous Systemic Steroid Treatment
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DOI: 10.1155/2018/4258763
Abstract: Purpose To investigate the effectiveness of mineralocorticoid receptor (MR) antagonist in patients with steroid-induced central serous chorioretinopathy (CSC). Methods A retrospective review was conducted of steroid-induced CSC patients who were treated with the MR antagonist… read more here.
Keywords: treatment; steroid; steroid induced; mineralocorticoid receptor ... See more keywords
Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms
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DOI: 10.3389/fcvm.2023.1101389
Abstract: Background Abdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate the… read more here.
Keywords: aortic aneurysms; aaa model; spironolactone; abdominal aortic ... See more keywords