Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors
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DOI: 10.1002/ijc.34187
Abstract: Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow‐up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases… read more here.
Keywords: nevi melanoma; methylation; spitz nevi; melanocytic tumors ... See more keywords
Eruptive disseminated Spitz nevi – Case report☆☆☆
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DOI: 10.1016/j.abd.2019.01.010
Abstract: Spitz nevus is a benign melanocytic lesion, which presents in several ways: solitary, agminated, or disseminated. The disseminated variant is uncommon; it may have a rapid evolution (the eruptive form) and be difficult to manage.… read more here.
Keywords: disseminated spitz; spitz nevi; eruptive disseminated; report ... See more keywords
Fusion of ALK to the melanophilin gene MLPH in pediatric Spitz nevi.
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DOI: 10.1016/j.humpath.2019.03.002
Abstract: Spitzoid neoplasms typically affect young individuals and include Spitz nevus, atypical Spitz tumor, and Spitzoid melanoma. Spitz tumors can exhibit gene fusions involving the receptor tyrosine kinases NTRK1, NTRK3, ALK, ROS1, RET, or MET, or… read more here.
Keywords: spitz nevi; melanophilin; alk; fusion ... See more keywords
The Markers Auxiliary in Differential Diagnosis of Early Melanomas and Benign Nevi Sharing Some Similar Features Potentially Leading to Misdiagnosis – A Review of Immunohistochemical Studies
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DOI: 10.1080/07357907.2022.2134415
Abstract: Abstract Although most melanocytic skin lesions are correctly diagnosed, numerous studies have shown interobserver disagreement. This review analyzes 20 molecules as immunohistochemical markers for distinguishing dysplastic and/or Spitz nevi from early melanomas (in situ, Clark… read more here.
Keywords: review; markers auxiliary; early melanomas; spitz nevi ... See more keywords