Spitz Nevus and Other Spitzoid Tumors in Children -Part 1: Clinical, Histopathologic, and Immunohistochemical Features.
Sign Up to like & getrecommendations! Published in 2019 at "Actas dermo-sifiliograficas"
DOI: 10.1016/j.ad.2019.02.011
Abstract: A Spitz nevus is a melanocytic neoplasm of epithelioid and/or spindle cells that usually appears in childhood. These lesions are by nature benign, but their features can sometimes make them difficult to distinguish from melanomas.… read more here.
Keywords: spitzoid tumors; histopathologic; tumors children; nevus spitzoid ... See more keywords
Eruptive Spitz nevus, a striking example of benign metastasis
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DOI: 10.1038/s41598-020-73264-0
Abstract: Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified… read more here.
Keywords: example benign; nevus striking; metastasis; eruptive spitz ... See more keywords
ALK‐positive compound Spitz nevus with extensive perineural and intraneural neurotropism
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DOI: 10.1111/cup.13890
Abstract: Historically recognized by their characteristic histopathologic features, Spitz neoplasms are now known to be molecularly defined by mutually exclusive recurrent abnormalities that cause activation of the MAPK pathway. Spitz neoplasms with ALK rearrangements frequently demonstrate… read more here.
Keywords: neurotropism; compound spitz; alk positive; spitz ... See more keywords
Spitz nevus with EHBP1-ALK fusion and distinctive membranous localization of ALK.
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DOI: 10.1111/cup.14209
Abstract: ALK rearrangements define a histopathologically distinctive but diverse subset of Spitz tumors characterized by fusiform to epithelioid melanocytes with frequent fascicular growth and ALK overexpression. Molecularly, these tumors are characterized by fusions between ALK and… read more here.
Keywords: alk fusion; spitz nevus; alk; localization ... See more keywords