Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression
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DOI: 10.1097/wnr.0000000000001520
Abstract: Cervical nerve root injury induces a host of inflammatory mediators in the spinal cord that initiate and maintain neuronal hyperexcitability and pain. Secretory phospholipase A2 (sPLA2) is an enzyme that has been implicated as a… read more here.
Keywords: secretory phospholipase; spla2; neuronal hyperexcitability; nerve root ... See more keywords
Secretion of secretory phospholipase A2 into Spodoptera exigua larval midgut lumen and its role in lipid digestion
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DOI: 10.1111/imb.12588
Abstract: In insects, lipid digestion is controversial because insects have no bile salts to solubilize dietary lipids. One hypothesis is that a secretory type of phospholipase A2 (sPLA2) provides lysophospholipid (LPL) from dietary phospholipids (PLs). We… read more here.
Keywords: spla2; role lipid; secretion; spodoptera exigua ... See more keywords
Human Secretary Phospholipase A2 Mutations and Their Clinical Implications
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DOI: 10.2147/jir.s269557
Abstract: Abstract Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for hydrolysis of the sn-2 fatty acids of membrane phospholipids to release arachidonic acid. PLA2s are the rate limiting enzyme for the downstream synthesis… read more here.
Keywords: clinical implications; secretary phospholipase; mutations clinical; spla2 ... See more keywords
Secretory Phospholipase A2 Digital Expression Analysis in Colon Adenocarcinoma
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DOI: 10.21873/invivo.12760
Abstract: Background/Aim: Phospholipases A2 represent a family of enzymes that regulate the metabolism of phospholipids by hydrolyzing them into fatty acids. Secretory phospholipase A2 (SPLA2) catalyzes the calcium-dependent 2-acyl groups hydrolysis to produce 3-sn-phosphoglycerides. This study… read more here.
Keywords: colon adenocarcinoma; secretory phospholipase; spla2; expression ... See more keywords
Liposomes Targeting P21 Activated Kinase-1 (PAK-1) and Selective for Secretory Phospholipase A2 (sPLA2) Decrease Cell Viability and Induce Apoptosis in Metastatic Triple-Negative Breast Cancer Cells
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DOI: 10.3390/ijms21249396
Abstract: P21 activated kinases (or group I PAKs) are serine/threonine kinases whose expression is altered in prostate and breast cancers. PAK-1 activity is inhibited by the small molecule “Inhibitor targeting PAK-1 activation-3” (IPA-3), which has selectivity… read more here.
Keywords: spla2; sprl ipa; breast cancer; cell ... See more keywords