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Published in 2017 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2017.04.007
Abstract: Bloodstream infections that progress to septic shock are responsible for hundreds of thousands of deaths each year, and are associated with significant healthcare costs. Recent studies have shown that a member of the secreted phospholipase…
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Keywords:
plasma;
microsieve based;
iia;
microsieve assay ... See more keywords
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Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.04.015
Abstract: HIGHLIGHTSOleanolic acid suppresses inflammatory response in A&bgr;‐activated astrocyte.OA attenuates A&bgr;‐stimulated astrocytes‐induced neuronal growth inhibition.OA restrains A&bgr;‐induced expression and release of sPLA2‐IIA.OA protects against A&bgr;‐induced neurotoxicity by blocking sPLA2‐IIA‐evoked Ca2+ influx.OA ameliorates cognitive deficits and inflammatory…
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Keywords:
bgr activated;
neurotoxicity;
acid;
iia ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11830-9
Abstract: Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development…
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Keywords:
hair shaft;
differentiation;
iia;
healing response ... See more keywords
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Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152611
Abstract: Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase A2 (sPLA2-IIA) prevents bacterial infection by degrading bacterial membranes. Here, we show that, despite the restricted intestinal expression of sPLA2-IIA in BALB/c mice, its…
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Keywords:
gut microbiota;
iia;
spla2 iia;
group iia ... See more keywords
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Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152638
Abstract: Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently hydrolyzes…
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Keywords:
iia;
phospholipase iia;
microbiota;
spla2 iia ... See more keywords
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Published in 2017 at "Natural Product Communications"
DOI: 10.1177/1934578x1701200624
Abstract: The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone…
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Keywords:
group iia;
expression;
iia phospholipase;
secretory group ... See more keywords
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Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801300811
Abstract: The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin…
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Keywords:
group iia;
expression;
iia phospholipase;
secretory group ... See more keywords
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Published in 2017 at "International heart journal"
DOI: 10.1536/ihj.16-163
Abstract: Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in…
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Keywords:
phospholipase group;
group iia;
expression;
secretory phospholipase ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.966950
Abstract: Increasing evidence points to the involvement of group IIA secreted phospholipase A2 (sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity. Here, the role of this moonlighting protein has been deepened in the osteoclastogenesis process…
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Keywords:
osteoclastogenesis process;
group iia;
spla2 iia;
iia ... See more keywords