Distinguishing septic from normal donors by detection of sPLA2-IIA from human plasma using a microsieve-based immunoassay.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2017.04.007
Abstract: Bloodstream infections that progress to septic shock are responsible for hundreds of thousands of deaths each year, and are associated with significant healthcare costs. Recent studies have shown that a member of the secreted phospholipase… read more here.
Keywords: plasma; microsieve based; iia; microsieve assay ... See more keywords
Oleanolic acid protects against cognitive decline and neuroinflammation‐mediated neurotoxicity by blocking secretory phospholipase A2 IIA‐activated calcium signals
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.04.015
Abstract: HIGHLIGHTSOleanolic acid suppresses inflammatory response in A&bgr;‐activated astrocyte.OA attenuates A&bgr;‐stimulated astrocytes‐induced neuronal growth inhibition.OA restrains A&bgr;‐induced expression and release of sPLA2‐IIA.OA protects against A&bgr;‐induced neurotoxicity by blocking sPLA2‐IIA‐evoked Ca2+ influx.OA ameliorates cognitive deficits and inflammatory… read more here.
Keywords: bgr activated; neurotoxicity; acid; iia ... See more keywords
Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11830-9
Abstract: Secretory phospholipase A2 Group-IIA (sPLA2-IIA) is involved in lipid catabolism and growth promoting activity. sPLA2-IIA is deregulated in many pathological conditions including various cancers. Here, we have studied the role of sPLA2-IIA in the development… read more here.
Keywords: hair shaft; differentiation; iia; healing response ... See more keywords
Secretory phospholipase A2-IIA targets bacterial extracellular vesicles to modulate immune signaling
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-09025-4
Abstract: Secretory phospholipase A2-IIA (sPLA2-IIA) is a bactericidal enzyme that hydrolyzes membrane phospholipids, releasing lipid metabolites that can affect inflammation. sPLA2-IIA exhibits poor activity toward eukaryotic cells but preferentially targets gram-positive bacterial membranes. While sPLA2-IIA is… read more here.
Keywords: extracellular vesicles; phospholipase iia; bacterial extracellular; secretory phospholipase ... See more keywords
Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152611
Abstract: Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase A2 (sPLA2-IIA) prevents bacterial infection by degrading bacterial membranes. Here, we show that, despite the restricted intestinal expression of sPLA2-IIA in BALB/c mice, its… read more here.
Keywords: gut microbiota; iia; spla2 iia; group iia ... See more keywords
The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.152638
Abstract: Secreted phospholipase A2-IIA (sPLA2-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA2-IIA efficiently hydrolyzes… read more here.
Keywords: iia; phospholipase iia; microbiota; spla2 iia ... See more keywords
Inhibitory Effect of Zingerone on Secretory Group IIA Phospholipase A2
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Communications"
DOI: 10.1177/1934578x1701200624
Abstract: The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Zingerone… read more here.
Keywords: group iia; expression; iia phospholipase; secretory group ... See more keywords
Inhibitory Effect of Pelargonidin on Secretory Group IIA Phospholipase A2
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Communications"
DOI: 10.1177/1934578x1801300811
Abstract: The expression of secretory group IIA phospholipase A2 (sPLA2-IIA) has been shown to be elevated in various inflammatory diseases, and lipopolysaccharide (LPS) up-regulates the expression of sPLA2-IIA in human umbilical vein endothelial cells (HUVECs). Pelargonidin… read more here.
Keywords: group iia; expression; iia phospholipase; secretory group ... See more keywords
Effects of Statins and Xuezhikang on the Expression of Secretory Phospholipase A2, Group IIA in Rat Vascular Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2017 at "International heart journal"
DOI: 10.1536/ihj.16-163
Abstract: Atherosclerosis is a multifactorial vascular disease characterized by formation of inflammatory lesions. Secretory phospholipase A2, group IIA (sPLA2-IIA) is involved in this process and plays a critical role. However, the exact role of sPLA2-IIA in… read more here.
Keywords: phospholipase group; group iia; expression; secretory phospholipase ... See more keywords
Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.966950
Abstract: Increasing evidence points to the involvement of group IIA secreted phospholipase A2 (sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity. Here, the role of this moonlighting protein has been deepened in the osteoclastogenesis process… read more here.
Keywords: osteoclastogenesis process; group iia; spla2 iia; iia ... See more keywords