Chronic neurostimulation of splenic nerve enabled by hydrogel-bioelectronics for wireless electroceutical immunomodulation therapy
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DOI: 10.1093/nsr/nwaf557
Abstract: Targeted modulation of the splenic nerve offers a selective alternative to vagus nerve stimulation, avoiding off-target activation of mixed vagal fibers. However, the small diameter and anatomical complexity of splenic nerve pose great challenges for… read more here.
Keywords: nerve; electroceutical immunomodulation; immunomodulation therapy; splenic nerve ... See more keywords
Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs
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DOI: 10.3389/fimmu.2021.649786
Abstract: Neuromodulation of the immune system has been proposed as a novel therapeutic strategy for the treatment of inflammatory conditions. We recently demonstrated that stimulation of near-organ autonomic nerves to the spleen can be harnessed to… read more here.
Keywords: chronically implanted; stimulation; nerve neuromodulation; neuromodulation ... See more keywords