Invention and Early History of Exon Skipping and Splice Modulation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8651-4_1
Abstract: Since its discovery in 1977, much has been known about RNA splicing and how it plays a central role in human development, function, and, notably, disease. Defects in RNA splicing account for at least 10%… read more here.
Keywords: modulation; exon skipping; splice modulation; invention ... See more keywords
Stereochemical Control of Splice Modulation in FD-895 Analogues.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01893
Abstract: Highly functionalized skeletons of macrolide natural products gain access to rare spatial arrangements of atoms, where changes in stereochemistry can have a profound impact on the structure and function. Spliceosome modulators present a unique consensus… read more here.
Keywords: 895 analogues; control splice; modulation 895; chemistry ... See more keywords
Splice Modulation Synergizes Cell Cycle Inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00833
Abstract: While recognized as a therapeutic target, the spliceosome may offer a robust vector to improve established therapeutics against other protein targets. Here, we describe how modulating the spliceosome using small molecule splice modulators (SPLMs) can… read more here.
Keywords: cell; inhibition; cell cycle; splice modulation ... See more keywords