A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13401
Abstract: The efficacy of anti-angiogenic treatment by targeting VEGF/VEGF receptors in metastatic clear cell renal cell carcinoma (ccRCC) varies from patient to patient. Discovering the reasons behind this variability could lead to the identification of relevant… read more here.
Keywords: cell; renal cell; vegf; therapeutic targets ... See more keywords
Alternative LIM homeodomain splice variants are dynamically regulated at key developmental steps in vertebrates
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.466
Abstract: Alternative splicing provides a broad strategy to amplify the genome. Yet how alternative splicing influences neurodevelopment or indeed which variants are translated at developmental choice points remains poorly explored. Here we focused on a gene… read more here.
Keywords: lim homeodomain; homeodomain splice; alternative lim; splice variants ... See more keywords
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55858-5_3
Abstract: Mammalian Na+/Ca2+ exchangers (NCX1, NCX2, and NCX3) and their splice variants are expressed in a tissue-specific manner and are regulated by Ca2+ binding CBD1 and CBD2 domains. NCX2 does not undergo splicing, whereas in NCX1… read more here.
Keywords: cbds; splice variants; ca2 binding; ca2 ... See more keywords
RNA Binding by the KTS Splice Variants of the Wilms' Tumor Suppressor Protein WT1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00602
Abstract: The Wilms' tumor suppressor protein WT1 regulates the expression of multiple genes through binding of the Cys2-His2 zinc-finger domain to promoter sites. WT1 has also been proposed to be involved in post-transcriptional regulation, by binding… read more here.
Keywords: zinc; splice variants; kts; wt1 ... See more keywords
Altered expression of CSF3R splice variants impacts signal response and is associated with SRSF2 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0567-9
Abstract: Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20… read more here.
Keywords: splice variants; expression csf3r; expression; csf3r ... See more keywords
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11580-4
Abstract: Neuropilin-1 (NRP1) is an essential transmembrane receptor with a variety of cellular functions. Here, we identify two human NRP1 splice variants resulting from the skipping of exon 4 and 5, respectively, in colorectal cancer (CRC).… read more here.
Keywords: splice; splice variants; metastasis; met integrin ... See more keywords
Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55460-9
Abstract: Nectin-4 cell adhesion molecule and ErbB2 tyrosine kinase receptor are upregulated in many cancers, including breast cancer, and promote cancer cell proliferation and metastasis. Using human breast cancer cell lines T47D and SUM190-PT, in which… read more here.
Keywords: trastuzumab resistant; splice variants; nectin cis; activation ... See more keywords
Restrained expression of canine glucocorticoid receptor splice variants α and P prognosticates fatal disease outcome in SIRS
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03451-0
Abstract: Glucocorticoids play a central role in the inflammatory response and alleviate the symptoms in critically ill patients. The glucocorticoid action relies on the glucocorticoid receptor (GR) which translocates into the nucleus upon ligand-binding and regulates… read more here.
Keywords: expression; glucocorticoid receptor; splice variants; cgr ... See more keywords
Differential functions of the KRAS splice variants.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221347
Abstract: RAS proteins are small GTPases that transduce signals from membrane receptors to signaling pathways that regulate growth and differentiation. Four RAS proteins are encoded by three genes - HRAS, KRAS, NRAS. Among them, KRAS is… read more here.
Keywords: functions kras; kras splice; differential functions; splice variants ... See more keywords
Novel IGF2BP1 splice variants, expression and their association with growth traits in goose
Sign Up to like & getrecommendations! Published in 2022 at "British Poultry Science"
DOI: 10.1080/00071668.2022.2094220
Abstract: ABSTRACT 1. The gene IGF2BP1 has been reported as being related to the body size and body weight in ducks, goats and chickens. However, this potential growth-related gene has not yet been reported in geese.… read more here.
Keywords: goose igf2bp1; novel igf2bp1; igf2bp1 splice; growth ... See more keywords
Assessing SPP1/Osteopontin (OPN) Splice Variants and Their Association to Nonmelanoma Skin Cancer by Absolute Quantification: Identification of OPN-5 Subvariants and Their Protein Coding Potential
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Investigation"
DOI: 10.1080/07357907.2021.1933015
Abstract: Abstract The study evaluated whether SPP1/osteopontin (OPN) splice variants are differentially expressed in nonmelanoma skin cancer compared to normal skin. The absolute number of mRNA molecules of OPN-a predominated in normal skin and nonmelanoma skin… read more here.
Keywords: nonmelanoma skin; splice variants; skin cancer; opn opn ... See more keywords