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   Articles with "spliced leader" as a keyword



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A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

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recommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"

DOI: 10.1016/j.ijpddr.2019.04.001

Abstract: Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control… read more here.

Keywords: leader trans; spliced leader; anthelmintic drugs; trans splicing ... See more keywords
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The nuclear RNA binding protein RBP33 influences mRNA and spliced leader RNA abundance in Trypanosoma brucei.

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recommendations! Published in 2017 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2016.12.008

Abstract: RNA recognition motif (RRM) containing proteins are important regulators of gene expression in trypanosomes. Here we expand our current knowledge on the exclusively nuclear localized RRM domain containing protein RBP33 of Trypanosoma brucei. Overexpression of… read more here.

Keywords: spliced leader; rna; trypanosoma brucei; protein rbp33 ... See more keywords
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slORFfinder: a tool to detect open reading frames resulting from trans-splicing of spliced leader sequences

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recommendations! Published in 2023 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbac610

Abstract: Abstract Trans-splicing of a spliced leader (SL) to the 5′ ends of mRNAs is used to produce mature mRNAs in several phyla of great importance to human health and the marine ecosystem. One of the… read more here.

Keywords: reading frames; tool; trans splicing; spliced leader ... See more keywords
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SL-quant: a fast and flexible pipeline to quantify spliced leader trans-splicing events from RNA-seq data

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recommendations! Published in 2018 at "GigaScience"

DOI: 10.1093/gigascience/giy084

Abstract: Abstract Background The spliceosomal transfer of a short spliced leader (SL) RNA to an independent pre-mRNA molecule is called SL trans-splicing and is widespread in the nematode Caenorhabditis elegans. While RNA-sequencing (RNA-seq) data contain information… read more here.

Keywords: quant fast; spliced leader; seq data; rna seq ... See more keywords
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An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx500

Abstract: Abstract Spliced leader (SL) trans-splicing is a critical element of gene expression in a number of eukaryotic groups. This process is arguably best understood in nematodes, where biochemical and molecular studies in Caenorhabditis elegans and… read more here.

Keywords: leader trans; spliced leader; vivo genetic; role ... See more keywords