Identification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000176
Abstract: Proteasomal spliced peptides (PSPs) have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel neoantigens that can stimulate highly specific T cells. Much debate has… read more here.
Keywords: identification spliced; modified peptides; peptides pancreatic; spliced peptides ... See more keywords
Database search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes.
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202100226
Abstract: Unconventional epitopes presented by HLA class I complexes are emerging targets for T cell targeted immunotherapies. Their identification by mass spectrometry required development of novel methods to cope with the large number of theoretical candidates.… read more here.
Keywords: cis spliced; hla class; spliced peptides; class immunopeptidomes ... See more keywords
Global Identification of Post-Translationally Spliced Peptides with Neo-Fusion.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00651
Abstract: Post-translationally spliced peptides have recently garnered significant interest as potential targets for cancer immunotherapy and as contributors to autoimmune diseases such as type 1 diabetes, yet feasible identification methods for spliced peptides have yet to… read more here.
Keywords: post translationally; neo fusion; translationally spliced; spliced peptides ... See more keywords
An unexplored angle: T cell antigen discoveries reveal a marginal contribution of proteasome splicing to the immunogenic MHC class I antigen pool
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119736119
Abstract: In the current era of T cell–based immunotherapies, it is crucial to understand which types of MHC-presented T cell antigens are produced by tumor cells. In addition to linear peptide antigens, chimeric peptides are generated… read more here.
Keywords: cell; spliced peptides; contribution; pool ... See more keywords
Neo-Splicetopes in Tumor Therapy: A Lost Case?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849863
Abstract: Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive… read more here.
Keywords: splicetopes tumor; spliced peptides; tumor therapy; therapy lost ... See more keywords