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   Articles with "spliceosome assembly" as a keyword



Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2114092119

Abstract: Significance Pre-messenger RNA (pre-mRNA) splicing is a key regulatory step in gene expression. The splicing reaction is mediated by the spliceosome, a dynamic complex comprising five small nuclear ribonucleoproteins (snRNPs), which assembles onto each intron… read more here.

Keywords: spliceosome assembly; rgg; sequence specific; sequence ... See more keywords

Structural dynamics of the N-terminal domain and the Switch loop of Prp8 during spliceosome assembly and activation

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky242

Abstract: Abstract Precursor message RNA (pre-mRNA) splicing is executed by the spliceosome, a large ribonucleoprotein (RNP) machinery that is comparable to the ribosome. Driven by the rapid progress of cryo-electron microscopy (cryo-EM) technology, high resolution structures… read more here.

Keywords: spliceosome assembly; terminal domain; switch loop; structural dynamics ... See more keywords

Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes

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recommendations! Published in 2023 at "RNA"

DOI: 10.1261/rna.079273.122

Abstract: Premessenger RNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex that assembles in a highly regulated process on each intronic substrate. Most studies of splicing and spliceosomes have been carried out in human… read more here.

Keywords: spliceosome assembly; insights analysis; regulation insights; regulation ... See more keywords

A role for SNU66 in maintaining 5′ splice site identity during spliceosome assembly

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recommendations! Published in 2024 at "RNA"

DOI: 10.1261/rna.079971.124

Abstract: In spliceosome assembly, the 5′ splice site is initially recognized by U1 snRNA. U1 leaves the spliceosome during the assembly process, therefore other factors contribute to the maintenance of 5′ splice site identity as it… read more here.

Keywords: splice site; site identity; site; spliceosome assembly ... See more keywords