Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114092119
Abstract: Significance Pre-messenger RNA (pre-mRNA) splicing is a key regulatory step in gene expression. The splicing reaction is mediated by the spliceosome, a dynamic complex comprising five small nuclear ribonucleoproteins (snRNPs), which assembles onto each intron… read more here.
Keywords: spliceosome assembly; rgg; sequence specific; sequence ... See more keywords
Structural dynamics of the N-terminal domain and the Switch loop of Prp8 during spliceosome assembly and activation
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DOI: 10.1093/nar/gky242
Abstract: Abstract Precursor message RNA (pre-mRNA) splicing is executed by the spliceosome, a large ribonucleoprotein (RNP) machinery that is comparable to the ribosome. Driven by the rapid progress of cryo-electron microscopy (cryo-EM) technology, high resolution structures… read more here.
Keywords: spliceosome assembly; terminal domain; switch loop; structural dynamics ... See more keywords
Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079273.122
Abstract: Premessenger RNA splicing is catalyzed by the spliceosome, a multimegadalton RNA–protein complex that assembles in a highly regulated process on each intronic substrate. Most studies of splicing and spliceosomes have been carried out in human… read more here.
Keywords: spliceosome assembly; insights analysis; regulation insights; regulation ... See more keywords