Dysregulation of splicing variants and spliceosome components in breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0019
Abstract: The dysregulation of the splicing process has emerged as a novel hallmark of metabolic and tumor pathologies. In breast cancer (BCa), which represents the most diagnosed cancer type among women worldwide, the generation and/or dysregulation… read more here.
Keywords: dysregulation splicing; spliceosome components; splicing variants; breast cancer ... See more keywords
Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer
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DOI: 10.3390/cancers14071827
Abstract: Simple Summary High throughput exome sequencing approaches have disclosed recurrent cancer-associated mutations in spliceosomal components, which drive aberrant pre-mRNA processing events and support the tumor phenotype. At the same time, mutations in spliceosome genes and… read more here.
Keywords: spliceosome components; mutations core; core spliceosome; somatic mutations ... See more keywords