Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1185
Abstract: Genomic characterization of hematologic and solid cancers has revealed recurrent somatic mutations affecting genes encoding the RNA splicing factors SF3B1, U2AF1, SRSF2 and ZRSR2. Recent data reveal that these mutations confer an alteration of function… read more here.
Keywords: novel orally; h3b; h3b 8800; spliceosome mutant ... See more keywords
A Small-Molecule Splicing Modulator Targets Spliceosome-Mutant Cells.
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DOI: 10.1158/2159-8290.cd-rw2018-038
Abstract: The small molecule H3B-8800 binds to and modulates the SF3b complex to kill spliceosome-mutant cells. read more here.
Keywords: splicing modulator; mutant cells; molecule splicing; small molecule ... See more keywords