A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration
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DOI: 10.1093/procel/pwac008
Abstract: Emerging evidence suggests that intron-detaining transcripts (IDTs) are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively respond to environmental stimuli and stress. However, the underlying mechanisms of detained intron (DI) splicing… read more here.
Keywords: contributes neurodegeneration; rnps1; molecular brake; spliceosome pausing ... See more keywords