The Splicing Code Goes Deep
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.01.013
Abstract: The importance of genomic sequence context in generating transcriptome diversity through RNA splicing is independently unmasked by two studies in this issue (Jaganathan et al., 2019; Baeza-Centurion et al., 2019). read more here.
Keywords: goes deep; splicing code; code goes;
Photopigment genes, cones, and color update: disrupting the splicing code causes a diverse array of vision disorders
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2019.05.004
Abstract: The human long- and middle-wavelength sensitive cone opsin genes exhibit an extraordinary degree of haplotype diversity that results from recombination mechanisms that have intermixed the genes. As a first step in expression, genes-including the protein… read more here.
Keywords: photopigment genes; color; code; vision disorders ... See more keywords
Deep learning of the back-splicing code for circular RNA formation
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz382
Abstract: MOTIVATION Circular RNAs (circRNAs) are a new class of endogenous RNAs in animals and plants. During pre-RNA splicing, the 5' and 3' termini of exon(s) can be covalently ligated to form circRNAs through back-splicing (head-to-tail… read more here.
Keywords: rna; deep learning; formation; back splicing ... See more keywords
Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab533
Abstract: Abstract The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and instead is postulated to require a multitude of features embedded in the pre-mRNA strand. We… read more here.
Keywords: spliceosomal components; structural scaffold; early spliceosomal; splicing code ... See more keywords
Exonic splicing code and protein binding sites for calcium
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac270
Abstract: Abstract Auxilliary splicing sequences in exons, known as enhancers (ESEs) and silencers (ESSs), have been subject to strong selection pressures at the RNA and protein level. The protein component of this splicing code is substantial,… read more here.
Keywords: splicing code; protein binding; binding sites; hand ... See more keywords