Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia
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DOI: 10.1182/blood.2021015325
Abstract: Key Points A novel EVI1 splice isoform is frequently expressed in inv(3)/t(3;3) leukemia and drives myeloid transformation. Frequent SF3B1 mutations in inv(3)/t(3;3) leukemia generate a novel EVI1 isoform with an altered second zinc finger domain. read more here.
Keywords: evi1 splicing; splicing contributes; leukemia; evi1 ... See more keywords