Identification of alternative splicing-derived cancer neoantigens for mRNA vaccine development
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab553
Abstract: Messenger RNA (mRNA) vaccines have shown great potential for anti-tumor therapy due to the advantages in safety, efficacy and industrial production. However, it remains a challenge to identify suitable cancer neoantigens that can be targeted… read more here.
Keywords: derived cancer; alternative splicing; cancer neoantigens; splicing derived ... See more keywords
Abstract 448: Computational discovery and experimental validation of splicing-derived neoantigens
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-448
Abstract: RNA splicing is a central step in the regulation of gene expression, leading to the accurate assembly of viable mRNA isoforms. Errors in the splicing process are common in cancer and lead to the production… read more here.
Keywords: tumor specific; validation; discovery; derived neoantigens ... See more keywords