An unknown essential function of tRNA splicing endonuclease is linked to the integrated stress response and intron debranching.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad044
Abstract: tRNA splicing endonuclease (TSEN) has a well-characterized role in tRNA splicing, but also other functions. For yeast TSEN, these other functions include degradation of a subset of mRNAs that encode mitochondrial proteins and an unknown… read more here.
Keywords: function; splicing endonuclease; intron debranching; essential function ... See more keywords
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic acids research"
DOI: 10.1093/nar/gkaa438
Abstract: The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core… read more here.
Keywords: splicing endonuclease; pre trna; trna splicing; trna ... See more keywords