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   Articles with "splicing events" as a keyword



Transcriptome analysis of developing lens reveals abundance of novel transcripts and extensive splicing alterations

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-10615-4

Abstract: Lens development involves a complex and highly orchestrated regulatory program. Here, we investigate the transcriptomic alterations and splicing events during mouse lens formation using RNA-seq data from multiple developmental stages, and construct a molecular portrait… read more here.

Keywords: transcriptome analysis; lens development; analysis; novel transcripts ... See more keywords

Radiation exposure induces genome-wide alternative splicing events in Aedes aegypti mosquitoes

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-94529-6

Abstract: Sterile insect technique is a method to control insect pest populations by sterilizing males with ionizing radiation. However, radiation sickness lowers the fitness of sterilized males. In this study, we investigate impacts of ionizing radiation… read more here.

Keywords: alternative splicing; radiation; radiation exposure; splicing events ... See more keywords

Comprehensive analysis of prognosis-related alternative splicing events in ovarian cancer

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recommendations! Published in 2022 at "RNA Biology"

DOI: 10.1080/15476286.2022.2113148

Abstract: ABSTRACT Ovarian cancer (OV) is characterized by high incidence and poor prognosis. Increasing evidence indicates that aberrant alternative splicing (AS) events are associated with the pathogenesis of cancer. We examined prognosis-related alternative splicing events and… read more here.

Keywords: prognosis related; splicing events; prognosis; ovarian cancer ... See more keywords

CASH: a constructing comprehensive splice site method for detecting alternative splicing events

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recommendations! Published in 2018 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbx034

Abstract: &NA; RNA‐sequencing (RNA‐seq) can generate millions of reads to provide clues for analyzing novel or abnormal alternative splicing (AS) events in cells. However, current methods for exploring AS events are still far from being satisfactory.… read more here.

Keywords: srsf10 regulated; cash; comprehensive splice; regulated splicing ... See more keywords

Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay

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recommendations! Published in 2019 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkz193

Abstract: Abstract Nonsense-mediated decay (NMD) is a eukaryotic mRNA surveillance system that selectively degrades transcripts with premature termination codons (PTC). Many RNA-binding proteins (RBP) regulate their expression levels by a negative feedback loop, in which RBP… read more here.

Keywords: integrative transcriptomic; transcriptomic analysis; splicing events; nonsense mediated ... See more keywords

Manananggal - a novel viewer for alternative splicing events

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recommendations! Published in 2017 at "BMC Bioinformatics"

DOI: 10.1186/s12859-017-1548-5

Abstract: BackgroundAlternative splicing is an important cellular mechanism that can be analyzed by RNA sequencing. However, identification of splicing events in an automated fashion is error-prone. Thus, further validation is required to select reliable instances of… read more here.

Keywords: viewer alternative; manananggal novel; novel viewer; splicing events ... See more keywords

Characterization of alternative splicing events and prognostic signatures in gastric cancer

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recommendations! Published in 2024 at "Cancer Cell International"

DOI: 10.1186/s12935-024-03348-8

Abstract: Accumulating evidences indicate that the specific alternative splicing (AS) events are linked to the occurrence and prognosis of gastric cancer (GC). Nevertheless, the impact of AS is still unclear and needed to further elucidation. The… read more here.

Keywords: cancer; alternative splicing; splicing events; analysis ... See more keywords

A tale of two parasites: a glimpse into the RNA methylome of patient-derived Plasmodium falciparum and Plasmodium vivax isolates

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recommendations! Published in 2025 at "Malaria Journal"

DOI: 10.1186/s12936-025-05376-9

Abstract: Background Understanding the molecular mechanisms of the malarial parasites in hosts is crucial for developing effective treatments. Epitranscriptomic research on pathogens has unveiled the significance of RNA methylation in gene regulation and pathogenesis. We present… read more here.

Keywords: methylation; splicing events; rna; plasmodium ... See more keywords

Origin, Conservation, and Loss of Alternative Splicing Events that Diversify the Proteome in Saccharomycotina Budding Yeasts.

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recommendations! Published in 2020 at "RNA"

DOI: 10.1261/rna.075655.120

Abstract: Many eukaryotes use RNA processing, including alternative splicing, to express multiple gene products from the same gene. While the majority of mammalian genes are alternatively spliced, other eukaryotes use this process less frequently. The budding… read more here.

Keywords: saccharomycotina; splicing events; gene; alternative splicing ... See more keywords

Mis-Spliced Lr34 Transcript Events in Winter Wheat

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0171149

Abstract: Lr34 in wheat is a non-race-specific gene that confers resistance against multiple fungal pathogens. The resistant allele Lr34 and the susceptible allele Lr34s can be distinguished by three polymorphisms that cause alternation of deduced amino… read more here.

Keywords: mis spliced; wheat; mis splicing; splicing events ... See more keywords

Classification and Quantification of Unproductive Splicing Events

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recommendations! Published in 2025 at "Acta Naturae"

DOI: 10.32607/actanaturae.27572

Abstract: In eukaryotic cells, the nonsense-mediated decay (NMD) pathway degrades mRNAs with premature stop codons. The coupling between NMD and alternative splicing (AS) generates NMD-sensitive transcripts (NMD targets, NMDTs) that play an important role in the… read more here.

Keywords: classification; quantification unproductive; splicing events; classification quantification ... See more keywords