Transcriptome analysis of developing lens reveals abundance of novel transcripts and extensive splicing alterations
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10615-4
Abstract: Lens development involves a complex and highly orchestrated regulatory program. Here, we investigate the transcriptomic alterations and splicing events during mouse lens formation using RNA-seq data from multiple developmental stages, and construct a molecular portrait… read more here.
Keywords: transcriptome analysis; lens development; analysis; novel transcripts ... See more keywords
Comprehensive analysis of prognosis-related alternative splicing events in ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2113148
Abstract: ABSTRACT Ovarian cancer (OV) is characterized by high incidence and poor prognosis. Increasing evidence indicates that aberrant alternative splicing (AS) events are associated with the pathogenesis of cancer. We examined prognosis-related alternative splicing events and… read more here.
Keywords: prognosis related; splicing events; prognosis; ovarian cancer ... See more keywords
CASH: a constructing comprehensive splice site method for detecting alternative splicing events
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbx034
Abstract: &NA; RNA‐sequencing (RNA‐seq) can generate millions of reads to provide clues for analyzing novel or abnormal alternative splicing (AS) events in cells. However, current methods for exploring AS events are still far from being satisfactory.… read more here.
Keywords: srsf10 regulated; cash; comprehensive splice; regulated splicing ... See more keywords
Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz193
Abstract: Abstract Nonsense-mediated decay (NMD) is a eukaryotic mRNA surveillance system that selectively degrades transcripts with premature termination codons (PTC). Many RNA-binding proteins (RBP) regulate their expression levels by a negative feedback loop, in which RBP… read more here.
Keywords: integrative transcriptomic; transcriptomic analysis; splicing events; nonsense mediated ... See more keywords
Manananggal - a novel viewer for alternative splicing events
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1548-5
Abstract: BackgroundAlternative splicing is an important cellular mechanism that can be analyzed by RNA sequencing. However, identification of splicing events in an automated fashion is error-prone. Thus, further validation is required to select reliable instances of… read more here.
Keywords: viewer alternative; manananggal novel; novel viewer; splicing events ... See more keywords
Origin, Conservation, and Loss of Alternative Splicing Events that Diversify the Proteome in Saccharomycotina Budding Yeasts.
Sign Up to like & getrecommendations! Published in 2020 at "RNA"
DOI: 10.1261/rna.075655.120
Abstract: Many eukaryotes use RNA processing, including alternative splicing, to express multiple gene products from the same gene. While the majority of mammalian genes are alternatively spliced, other eukaryotes use this process less frequently. The budding… read more here.
Keywords: saccharomycotina; splicing events; gene; alternative splicing ... See more keywords
Mis-Spliced Lr34 Transcript Events in Winter Wheat
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0171149
Abstract: Lr34 in wheat is a non-race-specific gene that confers resistance against multiple fungal pathogens. The resistant allele Lr34 and the susceptible allele Lr34s can be distinguished by three polymorphisms that cause alternation of deduced amino… read more here.
Keywords: mis spliced; wheat; mis splicing; splicing events ... See more keywords
Prognostic Value and Potential Role of Alternative mRNA Splicing Events in Cervical Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00726
Abstract: Background Increasing evidence suggests that aberrant alternative splicing (AS) events are associated with progression of cancer. This study evaluated the prognostic value and clarify the role of AS events in cervical cancer (CC). Methods Based… read more here.
Keywords: events cervical; prognostic value; cervical cancer; cancer ... See more keywords
Genome-wide analysis of RNA-binding proteins co-expression with alternative splicing events in mitral valve prolapse
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1078266
Abstract: Objectives We investigated the role and molecular mechanisms of RNA-binding proteins (RBPs) and their regulated alternative splicing events (RASEs) in the pathogenesis of mitral valve prolapse (MVP). Methods For RNA extraction, we obtained peripheral blood… read more here.
Keywords: rna binding; splicing events; alternative splicing; analysis ... See more keywords
Extensive Changes in Transcription Dynamics Reflected on Alternative Splicing Events in Systemic Lupus Erythematosus Patients
Sign Up to like & getrecommendations! Published in 2021 at "Genes"
DOI: 10.3390/genes12081260
Abstract: In addition to increasing the complexity of the transcriptional output, alternative RNA splicing can lead to the reduction of mRNA translation or the production of non-functional or malfunctional proteins, thus representing a vital component of… read more here.
Keywords: systemic lupus; lupus erythematosus; extensive changes; changes transcription ... See more keywords
Identification of Alternative Splicing Events Associated with Paratuberculosis in Dairy Cattle Using Multi-Tissue RNA Sequencing Data
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030497
Abstract: Paratuberculosis is a major endemic disease caused by Mycobacterium avium subspecies paratuberculosis (MAP) infection and leads to huge economic loss in the dairy sector worldwide. Alternative splicing (AS) events, playing indispensable regulatory roles in many… read more here.
Keywords: splicing events; paratuberculosis; dairy; rna ... See more keywords