Bioinformatics detection of modulators controlling splicing factor‐dependent intron retention in the human brain
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24379
Abstract: Alternative RNA splicing is an important means of genetic control and transcriptome diversity. However, when alternative splicing events are studied independently, coordinated splicing modulated by common factors is often not recognized. As a result, the… read more here.
Keywords: detection modulators; intron retention; splicing factor; bioinformatics detection ... See more keywords
Splicing factor poly(rC)‐binding protein 1 is a novel and distinctive tumor suppressor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26873
Abstract: A lot of evidence has been found on the link between tumorigenesis and the aberrant expression of splicing factors. A number of splicing factors have been reported to be either oncogenic or overexpressed in cancer… read more here.
Keywords: protein; factor poly; splicing factor; cancer ... See more keywords
Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23477
Abstract: Aberrant alternative splicing (AS) profoundly affects tumorigenesis and cancer progression. Serine/arginine‐rich splicing factor 3 (SRSF3) regulates the AS of precursor mRNAs and acts as a proto‐oncogene in many tumors, but its function and potential mechanisms… read more here.
Keywords: cervical cancer; ddx5; srsf3; factor srsf3 ... See more keywords
Identification and subcellular localization of splicing factor arginine/serine-rich 10 in the microsporidian Nosema bombycis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of invertebrate pathology"
DOI: 10.1016/j.jip.2020.107441
Abstract: Splicing factors are important components of RNA editing in eukaryotic organisms and can produce many functional and coding genes, which is an indispensable step for the correct expression of corresponding proteins. In this study, we… read more here.
Keywords: splicing factor; bombycis; serine; factor arginine ... See more keywords
Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2018.12.002
Abstract: SDS22 is an ancient regulator of protein phosphatase-1 (PP1). Our crystal structure of SDS22 shows that its twelve leucine-rich repeats adopt a banana-shaped fold that is shielded from solvent by capping domains at its extremities.… read more here.
Keywords: splicing factor; phosphatase pp1; sds22; structure ... See more keywords
The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.01.011
Abstract: RNA-binding proteins play an important role in the regulation of post-transcriptional gene expression throughout the nervous system. This is underscored by the prevalence of mutations in genes encoding RNA splicing factors and other RNA-binding proteins… read more here.
Keywords: splicing factor; conserved alternative; alternative splicing; development ... See more keywords
Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00192
Abstract: Human polypyrimidine-binding splicing factor (PSF/SFPQ) is a tumor suppressor protein that regulates the gene expression of several proto-oncogenes and binds to the 5'-polyuridine negative-sense template (5'-PUN) of some RNA viruses. The activity of PSF is… read more here.
Keywords: structure; human polypyrimidine; transcript; rna ... See more keywords
Splicing Factor 1 Modulates Dietary Restriction and TORC1 Pathway Longevity in C. elegans
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature20789
Abstract: Ageing is driven by a loss of transcriptional and protein homeostasis and is the key risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic dysfunction associated with age therefore have the potential… read more here.
Keywords: homeostasis; restriction; splicing factor; torc1 pathway ... See more keywords
Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature23313
Abstract: This corrects the article DOI: 10.1038/nature20789 read more here.
Keywords: splicing factor; corrigendum splicing; factor modulates; dietary restriction ... See more keywords
RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0888-1
Abstract: Increasing evidence demonstrates that ubiquitin specific protease 39 (USP39) plays an oncogenic role in various human tumors. Here, using expression analysis of the publicly available Oncomine database, clinical glioma patient samples, and glioma cells, we… read more here.
Keywords: maturation; glioma; splicing factor; glioma cells ... See more keywords
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04815-3
Abstract: Most tumor cells take up more glucose than normal cells. Splicing dysregulation is one of the molecular hallmarks of cancer. However, the role of splicing factor in glucose metabolism and tumor development remains poorly defined.… read more here.
Keywords: tumor growth; splicing factor; srsf5; tumor ... See more keywords