Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000104
Abstract: Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is… read more here.
Keywords: nuclear speckles; splicing factors; gene expression; roles nuclear ... See more keywords
Mutations of RNA splicing factors in hematological malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.08.042
Abstract: Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes. These studies have identified… read more here.
Keywords: mutations rna; cancer; factors hematological; rna splicing ... See more keywords
Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.09.002
Abstract: Alternative splicing (AS) is generally regulated by trans-splicing factors that specifically bind to cis-elements in pre-mRNAs. The human genome encodes ∼1,500 RNA binding proteins (RBPs) that potentially regulate AS, yet their functions remain largely unknown.… read more here.
Keywords: machine learning; modeling predicting; activities trans; splicing factors ... See more keywords
Monovalent Ionic Atmosphere Modulates the Selection of Suboptimal RNA Sequences by Splicing Factors' RNA Recognition Motifs
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00110
Abstract: The U2AF2 splicing factor is involved in the RNA recognition of the pre-mRNA poly-pyrimidine signaling sequence. This protein contains two RRM domains connected by a flexible linker, which ensure the preferential selection of a poly-uridine… read more here.
Keywords: recognition; splicing factors; selection suboptimal; rna recognition ... See more keywords
Specific inhibition of splicing factor activity by decoy RNA oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09523-0
Abstract: Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there… read more here.
Keywords: specific inhibition; inhibition splicing; splicing factor; decoy oligonucleotides ... See more keywords
CRISPR artificial splicing factors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16806-4
Abstract: Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation. Here we report the engineering… read more here.
Keywords: casfx; crispr artificial; control; artificial splicing ... See more keywords
Integrated analysis of a compendium of RNA-Seq datasets for splicing factors
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DOI: 10.1038/s41597-020-0514-7
Abstract: A vast amount of public RNA-sequencing datasets have been generated and used widely to study transcriptome mechanisms. These data offer precious opportunity for advancing biological research in transcriptome studies such as alternative splicing. We report… read more here.
Keywords: analysis; analysis compendium; rna; integrated analysis ... See more keywords
Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07530-z
Abstract: Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain… read more here.
Keywords: tra2a tra2b; ildr1 ildr2; tra2b srsf1; splicing factors ... See more keywords
RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiac015
Abstract: RNA splicing, a crucial transesterification-based process by which noncoding regions are removed from premature RNA to create mature mRNA, regulates various cellular functions, such as proliferation, survival, and differentiation. Clinical and functional studies over the… read more here.
Keywords: rna splicing; novel therapeutic; factors normal; splicing factors ... See more keywords
Targeting splicing factors for cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "RNA"
DOI: 10.1261/rna.079585.123
Abstract: Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and… read more here.
Keywords: factors cancer; targeting splicing; splicing factors; cancer therapy ... See more keywords
The Role of Splicing Factors in Adipogenesis and Thermogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and Cells"
DOI: 10.14348/molcells.2023.2195
Abstract: Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid… read more here.
Keywords: role; splicing factors; adipogenesis thermogenesis; factors adipogenesis ... See more keywords