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   Articles with "splicing factors" as a keyword



PTBP1 Regulates DNMT3B Alternative Splicing by Interacting With RALY to Enhance the Radioresistance of Prostate Cancer

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202405997

Abstract: Radiotherapy is a curative arsenal for prostate cancer (PCa), but radioresistance seriously compromises its effectiveness. Dysregulated RNA splicing factors are extensively involved in tumor progression. Nonetheless, the role of splicing factors in radioresistance remains largely… read more here.

Keywords: splicing factors; dnmt3b; prostate cancer; pca ... See more keywords
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Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression

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recommendations! Published in 2020 at "BioEssays"

DOI: 10.1002/bies.202000104

Abstract: Nuclear speckles are eukaryotic nuclear bodies enriched in splicing factors. Their exact purpose has been a matter of debate. The different proposed roles of nuclear speckles are reviewed and an additional layer of function is… read more here.

Keywords: nuclear speckles; splicing factors; gene expression; roles nuclear ... See more keywords

SARS‐CoV‐2 NSP12 utilizes various host splicing factors for replication and splicing regulation

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recommendations! Published in 2024 at "Journal of Medical Virology"

DOI: 10.1002/jmv.29396

Abstract: The RNA‐dependent RNA polymerase (RdRp) is a crucial element in the replication and transcription of RNA viruses. Although the RdRps of lethal human coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), SARS‐CoV, and Middle East… read more here.

Keywords: sars cov; replication; host; splicing factors ... See more keywords

The role of alternative splicing and splicing factors in diabetes: Current status and future perspectives

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recommendations! Published in 2024 at "Wiley Interdisciplinary Reviews: RNA"

DOI: 10.1002/wrna.1831

Abstract: With glucose being at the center of energy consumption and production, maintaining homeostasis of this simple sugar is of pivotal importance. Loss of glucose homeostasis results in altered blood glucose levels, that are frequently observed… read more here.

Keywords: splicing splicing; alternative splicing; splicing factors; diabetic conditions ... See more keywords
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Mutations of RNA splicing factors in hematological malignancies.

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recommendations! Published in 2017 at "Cancer letters"

DOI: 10.1016/j.canlet.2017.08.042

Abstract: Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes. These studies have identified… read more here.

Keywords: mutations rna; cancer; factors hematological; rna splicing ... See more keywords
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Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.

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recommendations! Published in 2018 at "Cell systems"

DOI: 10.1016/j.cels.2018.09.002

Abstract: Alternative splicing (AS) is generally regulated by trans-splicing factors that specifically bind to cis-elements in pre-mRNAs. The human genome encodes ∼1,500 RNA binding proteins (RBPs) that potentially regulate AS, yet their functions remain largely unknown.… read more here.

Keywords: machine learning; modeling predicting; activities trans; splicing factors ... See more keywords

Monovalent Ionic Atmosphere Modulates the Selection of Suboptimal RNA Sequences by Splicing Factors' RNA Recognition Motifs

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recommendations! Published in 2023 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.3c00110

Abstract: The U2AF2 splicing factor is involved in the RNA recognition of the pre-mRNA poly-pyrimidine signaling sequence. This protein contains two RRM domains connected by a flexible linker, which ensure the preferential selection of a poly-uridine… read more here.

Keywords: recognition; splicing factors; selection suboptimal; rna recognition ... See more keywords

Specific inhibition of splicing factor activity by decoy RNA oligonucleotides

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-09523-0

Abstract: Alternative splicing, a fundamental step in gene expression, is deregulated in many diseases. Splicing factors (SFs), which regulate this process, are up- or down regulated or mutated in several diseases including cancer. To date, there… read more here.

Keywords: specific inhibition; inhibition splicing; splicing factor; decoy oligonucleotides ... See more keywords

CRISPR artificial splicing factors

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-16806-4

Abstract: Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation. Here we report the engineering… read more here.

Keywords: casfx; crispr artificial; control; artificial splicing ... See more keywords

Integrated analysis of a compendium of RNA-Seq datasets for splicing factors

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recommendations! Published in 2020 at "Scientific Data"

DOI: 10.1038/s41597-020-0514-7

Abstract: A vast amount of public RNA-sequencing datasets have been generated and used widely to study transcriptome mechanisms. These data offer precious opportunity for advancing biological research in transcriptome studies such as alternative splicing. We report… read more here.

Keywords: analysis; analysis compendium; rna; integrated analysis ... See more keywords

Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-07530-z

Abstract: Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain… read more here.

Keywords: tra2a tra2b; ildr1 ildr2; tra2b srsf1; splicing factors ... See more keywords