Impact of Alternative Splicing on the Human Proteome
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.07.025
Abstract: Summary Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, we have developed… read more here.
Keywords: impact alternative; splicing human; impact; human proteome ... See more keywords
ASCancer Atlas: a comprehensive knowledgebase of alternative splicing in human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac955
Abstract: Abstract Alternative splicing (AS) is a fundamental process that governs almost all aspects of cellular functions, and dysregulation in this process has been implicated in tumor initiation, progression and treatment resistance. With accumulating studies of… read more here.
Keywords: splicing human; ascancer atlas; alternative splicing; comprehensive knowledgebase ... See more keywords
Aberrant splicing in human cancer: An RNA structural code point of view
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1137154
Abstract: Alternative splicing represents an essential process that occurs widely in eukaryotes. In humans, most genes undergo alternative splicing to ensure transcriptome and proteome diversity reflecting their functional complexity. Over the last decade, aberrantly spliced transcripts… read more here.
Keywords: rna structural; aberrant splicing; splicing human; human cancer ... See more keywords