A Truncated Form of the p27 Cyclin-Dependent Kinase Inhibitor Translated from Pre-mRNA Causes G2-Phase Arrest
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DOI: 10.1128/mcb.00217-22
Abstract: Pre-mRNA splicing is an indispensable mechanism for eukaryotic gene expression. Splicing inhibition causes cell cycle arrest at the G1 and G2/M phases, and this is thought to be one of the reasons for the potent… read more here.
Keywords: pre mrna; splicing inhibition; p27; phase arrest ... See more keywords
Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation
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DOI: 10.1158/1538-7445.sabcs18-4731
Abstract: Mutations in RNA splicing factors commonly occur in myeloid leukemia and solid tumors. These mutations occur in a heterozygous manner and confer dependency on the wild-type allele. Studies have shown that splicing factor mutant cancers… read more here.
Keywords: protein arginine; therapeutic targeting; inhibition protein; targeting rna ... See more keywords