Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds
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DOI: 10.3390/ijms21062026
Abstract: Human transcriptomes are more divergent than genes and contribute to the sophistication of life. This divergence is derived from various isoforms arising from alternative splicing. In addition, alternative splicing regulated by spliceosomal factors and RNA… read more here.
Keywords: transcriptomes mrna; divergent transcriptomes; mrna splicing; splicing modulation ... See more keywords
Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition
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DOI: 10.3390/ijms24032410
Abstract: Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth… read more here.
Keywords: mdm2 inhibition; splicing modulation; mdm2; modulation results ... See more keywords
Splicing Modulation as a Promising Therapeutic Strategy for Lysosomal Storage Disorders: The Mucopolysaccharidoses Example
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DOI: 10.3390/life12050608
Abstract: Over recent decades, the many functions of RNA have become more evident. This molecule has been recognized not only as a carrier of genetic information, but also as a specific and essential regulator of gene… read more here.
Keywords: lysosomal storage; splicing modulation; therapeutic strategy;