Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators
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DOI: 10.1021/acs.jcim.9b00635
Abstract: Splicing modulators (SMs) pladienolides, herboxidienes and spliceostatins exert their antitumor activity by altering the ability of SF3B1 and PHF5A proteins, components of SF3b splicing factor, to recognize distinct intron branching point sequences, thus finely calibrating… read more here.
Keywords: structural information; sf3b1; cryo structural; information ... See more keywords