Schwann cell-specific Dp116 is expressed in glioblastoma cells, revealing two novel DMD gene splicing patterns
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100703
Abstract: Background The DMD gene is one of the largest human genes, being composed of 79 exons. Dystrophin Dp116 expressed from the promoter in intron 55 is a Schwann cell-specific isoform. The pathophysiological roles of Dp116… read more here.
Keywords: dmd gene; glioblastoma; dp116 expressed; splicing patterns ... See more keywords
Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2018.1417390
Abstract: ABSTRACT Introduction: Mutations in genes associated with splicing have been found in hematologic malignancies, but also in solid cancers. Aberrant cancer specific RNA splicing either results from mutations or misexpression of the spliceosome genes directly,… read more here.
Keywords: therapeutic targets; splicing patterns; cancer; rna splicing ... See more keywords
Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddz094
Abstract: Abstract Changes to islet cell identity in response to type 2 diabetes (T2D) have been reported in rodent models, but are less well characterized in humans. We assessed the effects of aspects of the diabetic… read more here.
Keywords: hormone; splicing patterns; expression; cellular stressors ... See more keywords
Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0555
Abstract: Disruption of splicing patterns due to mutations of genes coding splicing factors in tumors represents a potential source of tumor neo-antigens, which would be both public (shared between patients) and tumor-specific (not expressed in normal… read more here.
Keywords: tumor specific; specific neo; neo antigens; sf3b1 mutated ... See more keywords
Differential RNA splicing as a potentially important driver mechanism in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.235424
Abstract: Disruption of the normal splicing patterns of RNA is a major factor in the pathogenesis of a number of diseases. Increasingly research has shown the strong influence that splicing patterns can have on cancer progression.… read more here.
Keywords: differential rna; myeloma; splicing patterns; multiple myeloma ... See more keywords