EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac154
Abstract: Abstract Alternative splicing is a key regulatory process underlying the amplification of genomic information and the expansion of proteomic diversity, particularly in brain. Here, we identify the Ewing sarcoma protein (EWS) as a new player… read more here.
Keywords: splicing regulation; alternative splicing; neuronal differentiation; differentiation ... See more keywords
An engineered RNA binding protein with improved splicing regulation
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx1304
Abstract: Abstract The muscleblind-like (MBNL) family of proteins are key developmental regulators of alternative splicing. Sequestration of MBNL proteins by expanded CUG/CCUG repeat RNA transcripts is a major pathogenic mechanism in the neuromuscular disorder myotonic dystrophy… read more here.
Keywords: protein; mbnl; rna binding; activity ... See more keywords
Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn5732
Abstract: IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human β cells, fostering autoantigen presentation… read more here.
Keywords: hla class; regulation nlrc5; pancreatic cells; nlrc5 shape ... See more keywords
Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11050666
Abstract: The reactivation of telomerase in cancer cells remains incompletely understood. The catalytic component of telomerase, hTERT, is thought to be the limiting component in cancer cells for the formation of active enzymes. hTERT gene expression… read more here.
Keywords: cancer; alternative splicing; splicing regulation; telomerase htert ... See more keywords