Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms
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DOI: 10.1038/s41598-017-03180-3
Abstract: Epithelial-Splicing-Regulatory-Protein 1 (Esrp1) is a cell-type specific RNA-binding protein (RBP) that is essential for mammalian development through maintenance of epithelial cell properties including barrier function. Esrp1 also regulates splicing during the epithelial to mesenchymal transition… read more here.
Keywords: esrp1; protein; epithelial splicing; esrp1 isoforms ... See more keywords
Modeling splicing outcome by combining 5′ss strength and splicing regulatory elements
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac663
Abstract: Abstract Correct pre-mRNA processing in higher eukaryotes vastly depends on splice site recognition. Beyond conserved 5′ss and 3′ss motifs, splicing regulatory elements (SREs) play a pivotal role in this recognition process. Here, we present in… read more here.
Keywords: strength; splicing regulatory; splicing outcome; modeling splicing ... See more keywords
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression
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DOI: 10.18632/oncotarget.20926
Abstract: KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which is involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions in different tissues and can have… read more here.
Keywords: regulatory protein; squamous cell; type splicing; splicing regulatory ... See more keywords
Mutations of Pre-mRNA Splicing Regulatory Elements: Are Predictions Moving Forward to Clinical Diagnostics?
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DOI: 10.3390/ijms18081668
Abstract: For more than three decades, researchers have known that consensus splice sites alone are not sufficient regulatory elements to provide complex splicing regulation. Other regulators, so-called splicing regulatory elements (SREs) are needed. Most importantly, their… read more here.
Keywords: elements predictions; mutations pre; mrna splicing; splicing regulatory ... See more keywords
A Regulatory Axis between Epithelial Splicing Regulatory Proteins and Estrogen Receptor α Modulates the Alternative Transcriptome of Luminal Breast Cancer
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DOI: 10.3390/ijms23147835
Abstract: Epithelial splicing regulatory proteins 1 and 2 (ESRP1/2) control the splicing pattern during epithelial to mesenchymal transition (EMT) in a physiological context and in cancer, including breast cancer (BC). Here, we report that ESRP1, but… read more here.
Keywords: splicing regulatory; estrogen receptor; epithelial splicing; regulatory proteins ... See more keywords