Transcriptome-wide decoding the roles of aberrant splicing in melanoma MAPK-targeted resistance evolution
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Reports"
DOI: 10.1038/s44319-025-00521-6
Abstract: Drug resistance critically limits the long-term efficacy of MAPK-targeted therapy in melanoma. While resistance mechanisms at genetic, epigenetic, and transcriptional scales are well-documented, post-transcriptional splicing regulation remains poorly understood. By analyzing patient-matched pre-treatment and resistant… read more here.
Keywords: mapk targeted; resistance; akt2; melanoma ... See more keywords
A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Cell reports"
DOI: 10.2139/ssrn.4287908
Abstract: Alternative splicing (AS) is a critical mechanism for the aberrant biogenesis of long non-coding RNA (lncRNA). Although the role of Wnt signaling in AS has been implicated, it remains unclear how it mediates lncRNA splicing… read more here.
Keywords: cell; lncrna dgcr5; wnt; splicing switch ... See more keywords