GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjac009
Abstract: Alternative splicing (AS) and transcription elongation are vital biological processes, and their dysregulation causes multiple diseases, including tumors. However, the co-regulatory mechanism of AS and transcription elongation in tumors remains unclear. This study demonstrates a… read more here.
Keywords: elongation; transcription elongation; zo1; alternative splicing ... See more keywords
Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0175523
Abstract: More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with… read more here.
Keywords: transcription; sf3b1k700e mutant; erythroid differentiation; splicing transcription ... See more keywords