Is the SPLUNC1-Orai1 axis a critical determinant of lung health?
Sign Up to like & getrecommendations! Published in 2025 at "Biochemical Society Transactions"
DOI: 10.1042/bst20241029
Abstract: Short palate lung and nasal epithelial clone 1 (SPLUNC1; gene name BPIFA1) is a secreted protein that is highly expressed in the nasopharyngeal and pulmonary systems. By data mining, we found that SPLUNC1 is also… read more here.
Keywords: critical determinant; axis critical; lung; splunc1 ... See more keywords
A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2020-0452oc
Abstract: Orai1 is a plasma membrane Ca2+ channel that mediates store operated Ca2+ entry (SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is an asthma gene modifier which inhibits Orai1/SOCE via… read more here.
Keywords: asthma model; inhibits orai1; microscopy; inflammation murine ... See more keywords
SPLUNC1 is a negative regulator of the Orai1 Ca2+ channel
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15306
Abstract: Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth… read more here.
Keywords: ca2; orai1; ca2 channel; splunc1 ... See more keywords