Application of definitions for conversion to secondary progressive MS in a Danish nationwide population.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.103319
Abstract: BACKGROUND The number of patients with relapsing remitting multiple sclerosis (RRMS) who convert to secondary progressive (SP) MS is uncertain, and with emerging treatment options for SPMS, it is important to identify RRMS patients in… read more here.
Keywords: spms; secondary progressive; disease modifying; multiple sclerosis ... See more keywords
Incidence, risk and prognosis of second primary malignancy of patients with gastric adenocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-56408-4
Abstract: Due to the long-term low survival rates of gastric adenocarcinoma (GAC) patients, the occurrence and prognosis of second primary malignancies (SPMs) are often underreported and overlooked as a significant concern.To date, only a few studies… read more here.
Keywords: history; gac; risk; spms ... See more keywords
Second Primary Malignancies Following a Diagnosis of Conjunctival Melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "Current eye research"
DOI: 10.1080/02713683.2021.2018465
Abstract: BACKGROUND Although incidence of second primary malignancies (SPMs) has been investigated in patients with cutaneous melanoma and uveal melanoma, limited studies have investigated their occurrence subsequent to conjunctival melanoma (CM). We conducted a retrospective observational… read more here.
Keywords: risk; second primary; diagnosis; primary malignancies ... See more keywords
Correlation between lymphoma and second primary malignant tumor
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033712
Abstract: Although studies have investigated the risk of second primary malignancies (SPMs) associated with lymphoma of various sites, limited studies have investigated risk of lymphoma with different SPMs and risk factors related to different SPMs. We… read more here.
Keywords: second primary; malignant tumor; primary malignant; risk ... See more keywords
Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-051921-084047
Abstract: Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety… read more here.
Keywords: toxicology; pharmacology; pro resolving; specialized pro ... See more keywords
Precursors of specialized pro-resolving mediators (SPMs) are decreased in hypertension, and treatment with SPMs improve vascular relaxation via formyl peptide-receptor-2
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731296
Abstract: Specialized pro-resolving mediators (SPMs), derived from essential fatty acids, play an immunoregulatory role. Formyl peptide receptor-1 is a pattern recognition receptor that mediate host-defense and inflammation. On the other hand, FPR2 binds SPMs to induce… read more here.
Keywords: inflammation; hypertension; physiology; treatment ... See more keywords
Disease-modifying therapies for relapsing/active secondary progressive multiple sclerosis – a review of population-specific evidence from randomized clinical trials
Sign Up to like & getrecommendations! Published in 2023 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864221146836
Abstract: Although the understanding of secondary progressive multiple sclerosis (SPMS) is evolving, early detection of relapse-independent progression remains difficult. This is further complicated by superimposed relapses and compensatory mechanisms that allow for silent progression. The term… read more here.
Keywords: clinical trials; evidence; spms; population ... See more keywords
Second primary malignancies in multiple myeloma: Incidence, survival and prognostic factors from a large single-center observational study
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2213
Abstract: Introduction: The risk of second primary malignancies (SPMs) has emerged as a growing clinical concern in patients with multiple myeloma (MM) who currently achieve prolonged survival. The reported cumulative incidence of SPMs in MM has… read more here.
Keywords: center; spm; history; risk ... See more keywords
Time-stratified risk of second primary solid malignancies among follicular lymphoma survivors in the United States
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DOI: 10.1182/blood-2025-5371
Abstract: Introduction: Survivors of follicular lymphoma (FL) face an elevated risk of developing second primary malignancies (SPMs). The risk of SPMs varies over time and this time varying risk of SPMs is informative for SPM mitigation,… read more here.
Keywords: time; time stratified; surveillance; risk ... See more keywords
Incidence of second primary malignancies (SPMs) following bispecific antibody (BsAb) therapy for lymphoid malignancies: A descriptive analysis of clinical trials
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-8071
Abstract: INTRODUCTION Bispecific antibodies (BsAbs) have emerged as transformative therapies for hematologic malignancies, with several agents now approved for relapsed/refractory acute lymphoblastic leukemia (ALL), multiple myeloma (MM), and non-Hodgkin lymphoma (NHL). These therapies have demonstrated remarkable… read more here.
Keywords: therapy; analysis; spms following; clinical trials ... See more keywords
Conversion to secondary progressive multiple sclerosis: Multistakeholder experiences and needs in Italy
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DOI: 10.1371/journal.pone.0228587
Abstract: Background Conversion to secondary progressive multiple sclerosis (SPMS) is associated with a relatively poor prognosis, and SPMS is responsible for the majority of the social and economic costs associated with MS. Managing the Transition to… read more here.
Keywords: progressive multiple; spms; conversion secondary; multiple sclerosis ... See more keywords